The concept that certain drugs can cross the skin might be traced back to Ibn Sina, a Persian physician, who proposed that dermally applied drugs can have a local effect, but can also affect tissue immediately beneath the skin as well as more remote areas, and can be considered as one of the most ancient consideration of transdermal drug delivery.
The possibility of self-administration of a predetermined drug dose at defined time intervals makes it also the most convenient personalized point-of-care approach.
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